Izaiah J. Ornelas

The paper maps transcription factor effector domains in plants and compares their function across eukaryotes, revealing conserved and lineage-specific regulatory principles.

CRISPRtune is a programmable tool that tunes transcriptional repression by fusing MeCP2 to dCas9, enabling intermediate gene expression control in human cells.

The paper develops a toolkit of chromatin regulators with cross-kingdom functionality for programmable transcriptional repression and activation in eukaryotic cells.

This paper introduces RENDER, a method for transient delivery of CRISPR-based epigenome editors as ribonucleoproteins to modulate gene expression in human cells, achieving durable epigenetic silencing.

This paper describes a protocol for CRISPRoff epigenetic editing to silence genes in human cells without DNA breaks, showing heritable transcriptional repression.