DEK::NUP214 acts as an XPO1-dependent transcriptional activator of essential leukemia genes
Fadimana Kaya, Findlay Bewicke‐Copley, Juho Jalmari Miettinen, Pedro Casado, Eve Leddy, Özgen Deniz, Vincent‐Philippe Lavallée, Céline Philippe, Jiexin Zheng, Florian Grebien, Naeem Khan, Szilvia Krizsán, Joseph J Saad, Alexis Nolin-Lapalme, Josée Hébert, , Ana Rio‐Machín
This study identifies DEK::NUP214 as an XPO1-dependent transcriptional activator of leukemia genes, showing selective response to XPO1 inhibitors in t(6;9) AML cases.
Leukemia · Apr 9, 2025Peer-reviewedCancer Biology