Dominique A. Bonnet

The paper shows that IFNg induces both stemness and differentiation in AML cells, leading to heterogeneous responses that affect leukemia growth and regeneration.

The paper uses intravital imaging to study dynamic remodelling of humanised bone marrow-like niches in mice, revealing vascular network formation and collagen matrix changes.

This study investigates how DNMT3A-R882 mutations affect HSC differentiation into immune cells, finding they drive dysfunctional neutropoiesis linked to immune dysregulation and inflammatory disease risk.

This study identifies DEK::NUP214 as an XPO1-dependent transcriptional activator of leukemia genes, showing selective response to XPO1 inhibitors in t(6;9) AML cases.

This study identifies granulocyte-derived resistin as a key factor in CMML that inhibits monocyte maturation and promotes immune suppression.

The paper identifies altered nucleocytoplasmic partitioning and nuclear accumulation of polyadenylated transcripts as conserved features of quiescence in neural stem cells.