Author

Eve Leddy

Queen Mary University of LondonORCID 0009-0009-8762-2710Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2 Genomics· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Research Focus:gene regulatory network inference· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Assay:CUT&Tag· 1

Frequent Co-Authors

Özgen DeniziD· 3 shared Aisha MoussaiD· 1 shared Alexis Nolin-LapalmeiD· 1 shared Alun Parsons· 1 shared Ana Rio‐MachíniD· 1 shared Caroline Akemi HeckmaniD· 1 shared Céline PhilippeiD· 1 shared Csaba BödöriD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersCancer Biology

Özgen DenizORCID

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3 papers

Recent·Most cited

GenomicsbioRxivPreprintSep 22, 2026

TEgment dissects transposable element reactivation upon CDK9 inhibition in acute myeloid leukemia

Dmitry Prokopov, Aisha Moussa, Hale Tunbak…·Özgen Deniz

The paper develops TEgment, a tool to analyze transposable element transcriptional modalities, showing that CDK9 inhibition leads to TE activation in AML through non-autonomous expression patterns.

DOI 10.64898/2026.09.16.752040

humanbulk RNA-seq

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Cancer BiologybioRxivPreprintNov 12, 2025

Epigenetic silencing of transposable elements by IRF2BP2 is a selective dependency of myeloid leukemia

Jingru Xu, Jessica Whittle, Liam Clayfield…·Georges Lacaud

This study identifies IRF2BP2 as a critical regulator of transposable element silencing in AML, showing its loss leads to TE activation and leukemia cell death.

DOI 10.1101/2025.11.12.688028

humanscRNA-seq

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Cancer BiologyLeukemiaPeer-reviewedApr 9, 2025

DEK::NUP214 acts as an XPO1-dependent transcriptional activator of essential leukemia genes

Fadimana Kaya, Findlay Bewicke‐Copley, Juho Jalmari Miettinen…·Ana Rio‐Machín

This study identifies DEK::NUP214 as an XPO1-dependent transcriptional activator of leukemia genes, showing selective response to XPO1 inhibitors in t(6;9) AML cases.

10 citationstop 2%

humanwhole-genome sequencing

𝕏 PostBluesky