A basic framework governing splice-site choice in eukaryotes
Craig Dent, Stefan Prodic, Aiswarya Balakrishnan, James Georges, Aaryan Chhabra, Sourav Mukherjee, Jordyn Coutts, Michael Gitonobel, Rucha D. Sarwade, Joseph Rosenbluh, Mauro D’Amato, Partha Pratim Das, Ya‐Long Guo, Alexandre Fournier‐Level, Richard Burke, , Sureshkumar Balasubramanian
The paper quantifies splice-site usage variation across species and identifies intronic hexamer sequences as key determinants of splice-site choice through GWAS and experimental validation.
bioRxiv · Mar 21, 2024 · PreprintGenetics