Mauro D’Amato

This study identifies maladaptive Piezo1 mechanotransduction as a driver of smooth muscle aging in the gut, showing it impairs contractility and contributes to gastrointestinal dysfunction.

This study identifies 619 IBD risk signals, resolves 81 high-confidence variants, and prioritizes 664 candidate effector genes using GWAS, eQTL, and exome sequencing.

This study shows that SI gene variants affect sucrose intake and preference in mice and humans, linking SI dysfunction to reduced consumption and disliking of sucrose-rich foods.

The paper quantifies splice-site usage variation across species and identifies intronic hexamer sequences as key determinants of splice-site choice through GWAS and experimental validation.

This study improves polygenic risk scores for colorectal cancer by combining Asian and European ancestry data, enhancing risk prediction across diverse racial and ethnic groups.

The paper links hubness in brain networks to embryonic neurogenesis, showing that earlier-born nodes become stronger hubs and are associated with genes related to neurological diseases.

This study performs a genome-wide association analysis of hemorrhoidal disease in 944,133 individuals, identifying 102 risk loci and linking them to vascular and tissue development pathways.

The paper identifies 31 host genetic loci influencing gut microbiome composition through GWAS and suggests causal effects in inflammatory diseases.

The paper identifies and characterizes prototypical pacemaker neurons in Hydra that express immune-related genes and interact with the microbial environment.

The paper identifies a genetic variant associated with cold adaptation in humans, showing a latitudinal cline and linking it to migraine prevalence.