David Powell

This study shows that transient cartilage-specific cell death in fetal mouse limbs is repaired through a two-step process involving delayed and then accelerated chondroprogenitor differentiation, with mTORC1 activation playing a key role in recovery.

The paper quantifies splice-site usage variation across species and identifies intronic hexamer sequences as key determinants of splice-site choice through GWAS and experimental validation.

This study identifies subregional cerebellar atrophy patterns in epilepsy syndromes using MRI data from 1,602 patients and 1,022 controls, finding significant volume loss in posterior lobe regions.

This study identifies NF-Y as a key regulator of both neuron-type-specific and pan-neuronal gene expression through direct and indirect mechanisms.

This paper develops a 3D spatial transcriptomic atlas of the mouse heart and provides a web tool for analysis and visualization.

The paper introduces a method to estimate splice-site strength and uses GWAS to identify genomic factors influencing splicing variation in Arabidopsis thaliana.

The paper analyzes transcriptomes of zebrafish atoh7 mutant embryos to identify Atoh7-dependent genetic networks linked to retinal development and human eye diseases.

Topconfects ranks differentially expressed genes by confident log fold change effect sizes, improving biological interpretation over p-value-based rankings.

The paper identifies GLD-2 mediated cytoplasmic polyadenylation targets in C. elegans and shows CCF-1 as the major deadenylase for maternal mRNA silencing.