A Mechanically Resilient Soft Hydrogel Improves Drug Delivery for Treating Post-Traumatic Osteoarthritis in Physically Active Joints
Nitin Joshi, Jing Yan, Mickael Dang, Kai V. Slaughter, Yufeng Wang, Dana Wu, Trevor Wai-Ming Ung, Bhingaradiya Nutan, Virja Pandya, Mu Xian Chen, Shahdeep Kaur, Sachin H. Bhagchandani, Haya A. Alfassam, John Joseph, Jingjing Gao, , Joerg Ermann
This paper develops a mechanically resilient hydrogel for drug delivery in physically active joints, showing sustained release and reduced cartilage degeneration in a mouse model of post-traumatic osteoarthritis.
Proceedings of the National Academy of Sciences · Mar 31, 2025Peer-reviewedBioengineering