Jingjing Gao

This study develops HDL-inspired lipid nanoparticles for targeted RNA delivery to the brain, showing improved BBB transport and cell-type-specific therapeutic effects in mouse models.

The paper screens lipid nanoparticles for intranasal RNA delivery to reduce neuroinflammation after traumatic brain injury, identifying effective candidates that lower microRNA-9-5p and improve outcomes.

The paper investigates how mitochondrial translational activators (TAs) facilitate transcript-specific translation initiation by aligning mRNAs at the small mitoribosomal subunit.

The paper reports the cryo-EM structure of TXNL1-bound proteasome and identifies interactions critical for stress-induced degradation of TXNL1.

This study reveals the structural basis of the midnolin-proteasome pathway and shows that midnolin downregulation promotes myeloma cell survival by enhancing IRF4 expression.

This paper develops a mechanically resilient hydrogel for drug delivery in physically active joints, showing sustained release and reduced cartilage degeneration in a mouse model of post-traumatic osteoarthritis.