Mistrafficking of KCC2 promotes hyperexcitability in hippocampal circuitry in a murine model of Christianson Syndrome
Jamie Mustian, Haoyi Qiu, Andy Y. L. Gao, Cong Loc Dang, Seyed Ehsan Vasegh, Bastien Castagner, John Orlowski, Reza Sharif‐Naeini, Rebecca Anne McKinney
The paper identifies endosomal dysfunction in a murine model of Christianson Syndrome as a cause of inhibitory circuit hyperexcitability through KCC2 mistrafficking.
bioRxiv · Sep 12, 2026 · PreprintNeuroscience