Rebecca Anne McKinney

Mistrafficking of KCC2 promotes hyperexcitability in hippocampal circuitry in a murine model of Christianson Syndrome

The paper identifies endosomal dysfunction in a murine model of Christianson Syndrome as a cause of inhibitory circuit hyperexcitability through KCC2 mistrafficking.

Zebrin molecular identity and cerebellar location determine Purkinje cell vulnerability in Christianson syndrome mice

This study shows that zebrin molecular identity and cerebellar location determine Purkinje cell vulnerability in Christianson syndrome mice, with anterior zebrin-negative cells dying earlier than posterior cells.

Synaptopodin is required for long-term depression at Schaffer collateral-CA1 synapses

This study shows that synaptopodin is essential for long-term depression at Schaffer collateral-CA1 synapses but not for long-term potentiation.

Loss of synaptopodin impairs mGluR5 and protein synthesis dependent mGluR-LTD at CA3-CA1 synapses

This study shows that loss of synaptopodin impairs mGluR5-dependent mGluR-LTD at CA3-CA1 synapses, leading to protein synthesis-independent LTD mediated by endocannabinoid signaling.

Blocking gephyrin phosphorylation or microglia BDNF signaling prevents synapse loss and reduces infarct volume after ischemia

Activity-dependent netrin-1 secretion drives synaptic insertion of GluA1-containing AMPA receptors in the hippocampus.

This study identifies netrin-1 as an activity-dependent effector of synaptic plasticity by promoting GluA1-containing AMPAR insertion at hippocampal synapses.