Dysregulation of NRSF/REST via EHMT1 is associated with psychiatric disorders
Mouhamed Alsaqati, Brittany A. Davis, Jamie Wood, Megan Jones, Lora Jones, Aishah Westwood, Olena Petter, Anthony R Isles, David E.J. Linden, Marianne B. M. van den Bree, Michael John Owen, Jérémy Hall, Adrian J. Harwood
The paper shows that reduced EHMT1 activity decreases NRSF/REST protein, leading to abnormal neuronal gene expression and neurodevelopmental issues in human iPSCs.
bioRxiv · Apr 26, 2021 · PreprintNeuroscience