Author

Brittany A. Davis

Johns Hopkins University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Neuroscience· 5

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 4 Approach:experimental assay· 4 Organism:human· 4 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 2 Assay:electronic health records· 2 Organism:mouse· 2

Frequent Co-Authors

Adrian J. HarwoodiD· 2 shared Andrew E. JaffeiD· 2 shared Anthony R IslesiD· 2 shared Brady J. MaheriD· 2 shared Madhavi TippaniiD· 2 shared Srinidhi Rao SripathyiD· 2 shared Aishah WestwoodiD· 1 shared Angéline Bilheu· 1 shared

Activity by Year

2019-2024 · peak 1/yr

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10 top collaborators · 12 mutual co-author links

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2 shared papersNeuroscience

Adrian J. HarwoodORCID

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5 papers

Recent·Most cited

TCF4 mutations disrupt synaptic function through dysregulation of RIMBP2 in patient-derived cortical neurons

Brittany A. Davis, Huei-Ying Chen, Zengyou Ye, Isaac Ostlund, Madhavi Tippani, Debamitra Das, Srinidhi Rao Sripathy, Yanhong Wang, Jacqueline M. Martín, Gina Shim, Neel M. Panchwagh, Rebecca L. Moses, Federica Farinelli, Joseph F. Bohlen, Meijie Li, , Brady J. Maher

This study shows TCF4 mutations impair synaptic function in patient-derived cortical neurons by disrupting RIMBP2 expression, leading to deficits in synaptic transmission and network excitability.

Biological Psychiatry · Apr 1, 2024Peer-reviewedNeuroscience

CaPTure: Calcium Peak Toolbox for analysis of in vitro calcium imaging data

Madhavi Tippani, Elizabeth A. Pattie, Brittany A. Davis, Claudia V. Nguyen, Yanhong Wang, Srinidhi Rao Sripathy, Brady J. Maher, Keri Martinowich, Andrew E. Jaffe, Stephanie C. Page

CaPTure is a scalable pipeline for analyzing calcium imaging data from cultured neurons, enabling high-throughput phenotypic discovery.

BMC Neuroscience · Nov 30, 2022Peer-reviewedNeuroscience

Dysregulation of NRSF/REST via EHMT1 is associated with psychiatric disorders

Mouhamed Alsaqati, Brittany A. Davis, Jamie Wood, Megan Jones, Lora Jones, Aishah Westwood, Olena Petter, Anthony R Isles, David E.J. Linden, Marianne B. M. van den Bree, Michael John Owen, Jérémy Hall, Adrian J. Harwood

The paper shows that reduced EHMT1 activity decreases NRSF/REST protein, leading to abnormal neuronal gene expression and neurodevelopmental issues in human iPSCs.

bioRxiv · Apr 26, 2021 · PreprintNeuroscience

Impairments in sensory-motor gating and information processing in a mouse model of Ehmt1 haploinsufficiency

Brittany A. Davis, François David, Ciara O’Regan, Manal A. Adam, Adrian J. Harwood, Vincenzo Crunelli, Anthony R Isles

This study examines information processing deficits in a mouse model of Ehmt1 haploinsufficiency, showing abnormalities in sensory-motor gating and electrophysiological responses.

Brain and Neuroscience Advances · Jan 1, 2020Peer-reviewedNeuroscience

Xenotransplanted human cortical neurons reveal species-specific development and functional integration into mouse visual circuits.

Daniele Linaro, Ben Vermaercke, Ryohei Iwata, Arjun Ramaswamy, Baptiste Libé‐Philippot, Leïla Boubakar, Brittany A. Davis, Keimpe D. B. Wierda, Kristofer Davie, Suresh Kumar Poovathingal, Pier-Andrée Penttilä, Angéline Bilheu, Lore De Bruyne, David Gall, Karl‐Klaus Conzelmann, , Pierre Vanderhaeghen

This study transplants human cortical neurons into mice to study their development and integration into mouse visual circuits, finding prolonged juvenile features and functional synaptic integration.

Neuron · Nov 21, 2019Peer-reviewedNeuroscience