Adrian J. Harwood

The paper investigates how loss-of-function and gain-of-function variants in CACNA1C affect neuronal networks and neurodevelopmental phenotypes through divergent mechanisms.

The paper identifies a gene regulatory network involving miRNAs that control neuronal differentiation by blocking REST through feedforward and feedback loops, with implications for neurodevelopmental disorders.

This study identifies neurogenic transcriptional programs linked to neuropsychiatric disorders and cognition using DLG2 knockout models and transcriptomic data.

This study investigates the effects of 1q21.1 deletion and duplication on neuronal development using induced pluripotent stem cells and shows reciprocal phenotypes and potential therapeutic targets.

The paper shows that reduced EHMT1 activity decreases NRSF/REST protein, leading to abnormal neuronal gene expression and neurodevelopmental issues in human iPSCs.

This study examines information processing deficits in a mouse model of Ehmt1 haploinsufficiency, showing abnormalities in sensory-motor gating and electrophysiological responses.

This study uses MEA assays to show that L-type calcium channel inhibitors affect synchronous firing in hiPSC-derived neuronal networks, suggesting their utility for studying psychiatric risk genes.

The paper develops REMI-seq methods to generate mutants and enable phenotyping in Dictyostelium, identifying novel regulators of cell migration and phagocytosis.

The paper generates genome-wide nucleosome maps in human iPSCs and neuronal progenitor cells, finding that positioned nucleosomes are sparse and dynamic but influence gene expression through structural changes rather than local transcriptional organization.