Author

Mouhamed Alsaqati

Cardiff UniversityORCID 0000-0001-8276-8854Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Research Focus:differential expression· 1 Research Focus:GWAS / association mapping· 1

Frequent Co-Authors

Adrian J. HarwoodiD· 3 shared Jérémy HalliD· 3 shared David E.J. LindeniD· 2 shared Marianne B. M. van den BreeiD· 2 shared Michael John OweniD· 2 shared Aishah WestwoodiD· 1 shared Anthony R IslesiD· 1 shared Brittany A. Davis· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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3 shared papersNeuroscience

Adrian J. HarwoodORCID

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3 papers

Recent·Most cited

NeurosciencebioRxivPreprintOct 16, 2023

Control of timing and directionality during neurodifferentiation of human induced Pluripotent Stem Cells (iPSC) via miRNA-mediated feedback and feedforward loops.

Jamie S Wood, Mouhamed Alsaqati, Jérémy Hall, Adrian J. Harwood

The paper identifies a gene regulatory network involving miRNAs that control neuronal differentiation by blocking REST through feedforward and feedback loops, with implications for neurodevelopmental disorders.

DOI 10.1101/2023.10.16.562489

humanbulk RNA-seq

𝕏 PostBluesky

NeuroscienceMolecular PsychiatryPeer-reviewedJun 10, 2021

Using induced pluripotent stem cells to investigate human neuronal phenotypes in 1q21.1 deletion and duplication syndrome.

Gareth Chapman, Mouhamed Alsaqati, Sharna Lunn…·Yasir Ahmed Syed

This study investigates the effects of 1q21.1 deletion and duplication on neuronal development using induced pluripotent stem cells and shows reciprocal phenotypes and potential therapeutic targets.

27 citations

humanexperimental assay

𝕏 PostBluesky

NeurosciencebioRxivPreprintApr 26, 2021

Dysregulation of NRSF/REST via EHMT1 is associated with psychiatric disorders

Mouhamed Alsaqati, Brittany A. Davis, Jamie Wood…·Adrian J. Harwood

The paper shows that reduced EHMT1 activity decreases NRSF/REST protein, leading to abnormal neuronal gene expression and neurodevelopmental issues in human iPSCs.

DOI 10.1101/2021.04.26.441439

humanbulk RNA-seq

𝕏 PostBluesky