Recombinant dimeric PDZ protein inhibitors for long-term relief of chronic pain by AAV therapeutics
Gith Noes‐Holt, Kathrine Louise Jensen, Mette Richner, Raquel Comaposada Baro, Line Sivertsen, Sara E. Jager, Lucía Jiménez-Fernández, Rita Chan Andersen, Jamila H. Lilja, Andreas Haahr Larsen, Marco B. K. Kowenicki, Sofie P. Boesgaard, Grace Anne Houser, Nikolaj Riis Christensen, Anke Tappe‐Theodor, , Andreas Toft Sørensen
This paper develops AAV-delivered dimeric peptide inhibitors of PICK1 to alleviate neuropathic pain in mice, showing long-term relief without adverse effects.
bioRxiv · Mar 3, 2023 · PreprintNeuroscience