Selection for targeted therapy resistance leads to an indirect selection for higher phenotypic plasticity and enhanced evolvability to orthogonal stressors
Alicia Bjornberg, Xierali Aobuli, Matthew Froid, Rowan Barker Clarke, Jeff Maltas, Robert Vander Velde, Jamir Riffas, Berkley E. Gryder, Alexander R.A. Anderson, Jacob G. Scott, David Basanta, Virginia A. Turati, Andriy Marusyk
The paper shows that targeted therapy resistance in cancer selects for cells with higher phenotypic plasticity, which enhances their ability to adapt to other stressors and promotes metastasis.
bioRxiv · Apr 3, 2026 · PreprintCancer Biology