Glucose limitation in Lactococcus shapes a single-peaked fitness landscape exposing membrane occupancy as a constraint
Claire E. Price, Filipe Branco dos Santos, Anne Hesseling, Jaakko J. Uusitalo, Herwig Bachmann, Vera Benavente, Anisha Goel, Jan Berkhout, Frank J. Bruggeman, Siewert J. Marrink, Manolo Montalban-Lopez, Anne de Jong, Jan Kok, Douwe Molenaar B, Bert Poolman, , Oscar Paul Kuipers
The paper shows a mutation in CcpA improves fitness in Lactococcus lactis by reprogramming transporters, revealing membrane occupancy as a constraint.
bioRxiv · Jun 8, 2017 · PreprintGenomics