Douwe Molenaar B

Proteome constraints reveal targets for improving microbial fitness in nutrient-rich environments

The paper identifies nutrient uptake constraints in Lactococcus lactis using a proteome-constrained model and experimental data, showing how these constraints influence metabolic fluxes and fitness in nutrient-rich environments.

A Systematic Assessment Of Current Genome-Scale Metabolic Reconstruction Tools

This paper systematically evaluates genome-scale metabolic reconstruction tools to determine their quality and suitability for different applications.

Integrated Stress Response Deregulation underlies Vanishing White Matter and is a target for therapy

ISRIB ameliorates ISR deregulation and clinical signs in VWM mice.

Glucose limitation in Lactococcus shapes a single-peaked fitness landscape exposing membrane occupancy as a constraint

The paper shows a mutation in CcpA improves fitness in Lactococcus lactis by reprogramming transporters, revealing membrane occupancy as a constraint.