Author

Herwig Bachmann

TiFNORCID 0000-0002-8224-0993Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 2 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Bas TeusinkiD· 2 shared Douwe Molenaar BiD· 2 shared Anisha GoeliD· 1 shared Anne de JongiD· 1 shared Anne Hesseling· 1 shared Berdien van OlstiD· 1 shared Bert PoolmaniD· 1 shared Claire E. Price· 1 shared

Activity by Year

2017-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersSystems Biology

Bas TeusinkORCID

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2 papers

Recent·Most cited

Proteome constraints reveal targets for improving microbial fitness in nutrient-rich environments

Yu Chen, Eunice van Pelt‐KleinJan, Berdien van Olst, Sieze Douwenga, Sjef A. Boeren, Herwig Bachmann, Douwe Molenaar B, Jens Nielsen, Bas Teusink

The paper identifies nutrient uptake constraints in Lactococcus lactis using a proteome-constrained model and experimental data, showing how these constraints influence metabolic fluxes and fitness in nutrient-rich environments.

Molecular Systems Biology · Apr 1, 2021Peer-reviewedSystems Biology

Glucose limitation in Lactococcus shapes a single-peaked fitness landscape exposing membrane occupancy as a constraint

Claire E. Price, Filipe Branco dos Santos, Anne Hesseling, Jaakko J. Uusitalo, Herwig Bachmann, Vera Benavente, Anisha Goel, Jan Berkhout, Frank J. Bruggeman, ‪Siewert J. Marrink, Manolo Montalban-Lopez, Anne de Jong, Jan Kok, Douwe Molenaar B, Bert Poolman, , Oscar Paul Kuipers

The paper shows a mutation in CcpA improves fitness in Lactococcus lactis by reprogramming transporters, revealing membrane occupancy as a constraint.

bioRxiv · Jun 8, 2017 · PreprintGenomics