Identification of a broad and potent V3 glycan site bNAb targeting anN332gp120 glycan-independent epitope
Lutz Gieselmann, Andrew T. DeLaitsch, Malena Rohde, Caelan E. Radford, Johanna Worczinski, Anna Momot, Elvin Ahmadov, Judith A. Burger, Colin Havenar‐Daughton, Sharvari Deshpande, Federico Giovannoni, Davide Corti, Christoph Kreer, Meryem Seda Ercanoglu, Philipp Schommers, , Florian Klein
This paper identifies a potent, broad neutralizing antibody targeting a glycan-independent V3 epitope on HIV-1 Env, showing enhanced neutralization potency and resistance to escape mutations.
bioRxiv · Sep 5, 2025 · PreprintImmunology