Caelan E. Radford

Mutations to the HCoV-229E spike have counterbalancing effects on serum antibody neutralization and receptor binding

The paper examines how mutations in the HCoV-229E spike affect receptor binding and serum neutralization, revealing counterbalancing effects on these functions.

Influenza hemagglutinin subtypes have different sequence constraints despite sharing extremely similar structures

The paper compares sequence constraints across influenza HA subtypes and finds that despite similar structures, ~50% of sites show diverged amino-acid preferences.

Identification of a broad and potent V3 glycan site bNAb targeting anN332gp120 glycan-independent epitope

This paper identifies a potent, broad neutralizing antibody targeting a glycan-independent V3 epitope on HIV-1 Env, showing enhanced neutralization potency and resistance to escape mutations.

Profiling a large HIV-1 elite neutralizer cohort reveals remarkable CD4bs bNAb for HIV-1 prevention and therapy

The paper identifies a new broadly neutralizing antibody, 04_A06, with high potency and breadth against HIV-1 strains, showing potential for prevention and therapy.

Determinants of human versus mosquito cell entry by the Chikungunya virus envelope proteins

This study identifies amino-acid mutations in CHIKV envelope proteins that affect entry in human and mosquito cells, revealing species-specific determinants of viral tropism.

Deep mutational scanning of rabies glycoprotein defines mutational constraint and antibody-escape mutations

This study uses deep mutational scanning to identify functional and antigenic effects of mutations in rabies glycoprotein, revealing escape mutations for antibodies and constrained regions for vaccine development.

Comprehensive maps of escape mutations from antibodies 10-1074 and 3BNC117 for Envs from two divergent HIV strains

This study maps escape mutations from antibodies 10-1074 and 3BNC117 against HIV Envs from two strains, showing differences in mutation effects between strains.

Functional and antigenic landscape of the Nipah virus receptor binding protein

This study uses deep mutational scanning to analyze how mutations in the Nipah virus receptor-binding protein affect function, receptor binding, and antibody escape, revealing constrained regions and limited antigenic variation in natural strains.