Florian Klein

The paper identifies gH/UL116 as a target for antibodies that neutralize HCMV and activate FcγR, showing its potential as a vaccine candidate.

This study demonstrates that lipid nanoparticle-formulated RNA encoding a potent HIV-1 neutralizing antibody can durably suppress viremia in humanized mice.

The paper identifies a broadly neutralizing antibody against multiple orthoebolaviruses from an rVSV-EBOV vaccinated individual and shows its protective efficacy in animal models.

This paper develops a consensus HCV E1E2 antigen that engages germline B cell precursors of broadly neutralizing antibodies.

This study uses cryo-EM to analyze antibodies targeting HCMV glycoproteins, identifying synergistic combinations that enhance neutralization.

This study compares T cell development in humanized mice with and without murine MHC, finding that busulfan conditioning in MHC-deficient mice promotes activated T cells while irradiation favors naive T cells.

This paper develops a multi-species luciferase-based double antigen ELISA for detecting H5 clade 2.3.4.4b-specific antibodies in various species, showing high sensitivity and specificity.

The paper assesses pre-existing humoral immunity against H5N1 clade 2.3.4.4b in unexposed individuals and finds low but distinct cross-neutralizing titers.

This paper identifies a potent, broad neutralizing antibody targeting a glycan-independent V3 epitope on HIV-1 Env, showing enhanced neutralization potency and resistance to escape mutations.

The paper identifies a new broadly neutralizing antibody, 04_A06, with high potency and breadth against HIV-1 strains, showing potential for prevention and therapy.

This paper develops a cell-cell fusion assay to study HCMV gH/gL/gO receptor engagement and its role in activating gB fusion, showing that PDGFR binding enhances fusion and can be blocked by neutralizing antibodies.