Christoph Kreer

B cell response to HCMV gH/UL116 elicits neutralizing and FcγR-activating antibodies

The paper identifies gH/UL116 as a target for antibodies that neutralize HCMV and activate FcγR, showing its potential as a vaccine candidate.

Identification of a pan-orthoebolavirus-reactive antibody from an rVSV-EBOV vaccinated individual

The paper identifies a broadly neutralizing antibody against multiple orthoebolaviruses from an rVSV-EBOV vaccinated individual and shows its protective efficacy in animal models.

Development of a multi-species luciferase-based double antigen ELISA for the detection of antibodies against Influenza A virus H5 clade 2.3.4.4b

This paper develops a multi-species luciferase-based double antigen ELISA for detecting H5 clade 2.3.4.4b-specific antibodies in various species, showing high sensitivity and specificity.

Detection of low pre-existing humoral immunity against influenza virus H5N1 clade 2.3.4.4b in unexposed individuals

The paper assesses pre-existing humoral immunity against H5N1 clade 2.3.4.4b in unexposed individuals and finds low but distinct cross-neutralizing titers.

Identification of a broad and potent V3 glycan site bNAb targeting anN332gp120 glycan-independent epitope

This paper identifies a potent, broad neutralizing antibody targeting a glycan-independent V3 epitope on HIV-1 Env, showing enhanced neutralization potency and resistance to escape mutations.

Profiling a large HIV-1 elite neutralizer cohort reveals remarkable CD4bs bNAb for HIV-1 prevention and therapy

The paper identifies a new broadly neutralizing antibody, 04_A06, with high potency and breadth against HIV-1 strains, showing potential for prevention and therapy.