let-7 miRNA and lin-46 mRNA are the two essential targets of the LIN28 RNA-binding protein in developmental timing
Jana Brunner, Anca Neagu, Dimos Gaidatzis, Lucas J Morales Moya, Helge Großhans
The paper identifies let-7 miRNA and lin-46 mRNA as the essential targets of LIN28 in C. elegans, showing they regulate developmental timing through coordinated control.
bioRxiv · Jan 14, 2026 · PreprintDevelopmental Biology