Helge Großhans

Cleavage of MEP-1 by DPF-3 Reveals Novel Substrate Specificity and Its Impact on Reproductive Fitness

The paper identifies MEP-1 as a novel substrate of DPF-3, showing cleavage after threonine and demonstrating its impact on reproductive fitness.

Large transgene arrays cause aberrant transcription and synthetic molting defects with myrf-1 mutation

The paper shows that large transgene arrays in C. elegans cause transcriptional dysregulation and synthetic molting defects when combined with a myrf-1 mutation.

let-7 miRNA and lin-46 mRNA are the two essential targets of the LIN28 RNA-binding protein in developmental timing

The paper identifies let-7 miRNA and lin-46 mRNA as the essential targets of LIN28 in C. elegans, showing they regulate developmental timing through coordinated control.

A conserved chronobiological complex times C. elegans development

This study identifies a conserved signaling module involving LIN-42 and KIN-20 that regulates molting timing in C. elegans, mirroring the mammalian PER-CK1 complex.

A scheduler for rhythmic gene expression

The paper develops a linear model to predict chromatin dynamics based on transcription factor binding in C. elegans, identifying key regulators that schedule gene expression rhythms.

Convergence of multiple RNA-silencing pathways on GW182/TNRC6

The paper identifies TRIM71's mechanism of mRNA silencing through recruitment of TNRC6/GW182 and shows competition among silencing pathways.

The Grainyhead/LSF transcription factor GRH-1 is rhythmically required for molting

The paper identifies GRH-1 as a transcription factor essential for rhythmic molting in C. elegans, showing its role in gene regulation and cuticle formation.

A folder mechanism ensures size uniformity among C. elegans individuals by coupling growth and development

The paper identifies a mechanism in C. elegans that maintains size uniformity by coupling growth rate and developmental duration through an oscillator.

The BLMP-1 transcription factor promotes oscillatory gene expression to achieve timely molting

The paper identifies BLMP-1 as a transcription factor that promotes oscillatory gene expression to regulate timely molting in C. elegans.

Protease-mediated processing of Argonaute proteins controls small RNA association

The paper shows that proteolytic processing of Argonaute proteins by DPF-3 regulates small RNA association, maintaining genome integrity and fertility in C. elegans.

Developmental function and state transitions of a gene expression oscillator in C. elegans

The paper characterizes a gene expression oscillator in C. elegans larvae, showing it starts in embryos, arrests transiently, and ceases in adults, operating near a SNIC bifurcation.

Two parallel arms of the heterochronic pathway direct coordinated juvenile-to-adult transition through distinct LIN-29 isoforms

The paper identifies two LIN-29 isoforms that regulate distinct aspects of the juvenile-to-adult transition in C. elegans through differential spatiotemporal expression and regulatory control by LIN-28, LIN-41, and HBL-1.

let-7 controls the transition to adulthood by releasing select transcriptional regulators from repression by LIN41

The paper shows let-7 miRNA promotes adult development in C. elegans by releasing LIN41 repression of multiple transcriptional targets involved in sexual organ development and skin progenitor cell fate changes.

Timing mechanism of sexually dimorphic nervous system differentiation

The paper identifies a regulatory pathway controlling the timing of sexual differentiation in C. elegans and shows its conservation in mice and humans.

Interplay of target site architecture and miRNA abundance determine miRNA activity and specificity

The paper shows that miRNA activity and specificity depend on both target site architecture and miRNA abundance, challenging the binary view of target site functionality.