Lucas J Morales Moya

The paper identifies let-7 miRNA and lin-46 mRNA as the essential targets of LIN28 in C. elegans, showing they regulate developmental timing through coordinated control.

This study identifies a conserved signaling module involving LIN-42 and KIN-20 that regulates molting timing in C. elegans, mirroring the mammalian PER-CK1 complex.

The paper characterizes a gene expression oscillator in C. elegans larvae, showing it starts in embryos, arrests transiently, and ceases in adults, operating near a SNIC bifurcation.

The paper measures the effect of Roscovitine on mPSM explants using a real-time reporter, finding increased oscillator period and differentiation rate, consistent with the clock and wavefront model requiring increased wavefront velocity.

This study develops a computational framework to reconstruct phase dynamics of the somitogenesis clock oscillator using empirical mode decomposition and validates it with synthetic data and real-time reporter signals.