Anca Neagu

let-7 miRNA and lin-46 mRNA are the two essential targets of the LIN28 RNA-binding protein in developmental timing

The paper identifies let-7 miRNA and lin-46 mRNA as the essential targets of LIN28 in C. elegans, showing they regulate developmental timing through coordinated control.

Convergence of multiple RNA-silencing pathways on GW182/TNRC6

The paper identifies TRIM71's mechanism of mRNA silencing through recruitment of TNRC6/GW182 and shows competition among silencing pathways.

Two parallel arms of the heterochronic pathway direct coordinated juvenile-to-adult transition through distinct LIN-29 isoforms

The paper identifies two LIN-29 isoforms that regulate distinct aspects of the juvenile-to-adult transition in C. elegans through differential spatiotemporal expression and regulatory control by LIN-28, LIN-41, and HBL-1.

let-7 controls the transition to adulthood by releasing select transcriptional regulators from repression by LIN41

The paper shows let-7 miRNA promotes adult development in C. elegans by releasing LIN41 repression of multiple transcriptional targets involved in sexual organ development and skin progenitor cell fate changes.