Quantifying Three-dimensional Chromatin Organization Utilizing Scanning Transmission Electron Microscopy: ChromSTEM
Yue Li, Eric W. Roth, Vasundhara Agrawal, Adam Eshein, Jane Fredrick, Luay Matthew Almassalha, Anne R. Shim, Reiner Bleher, Vinayak P. Dravid, Vadim Backman
The paper introduces ChromSTEM, a method to quantify 3D chromatin organization using electron microscopy, and finds chromatin is densely packed with heterochromatin having higher density than euchromatin.
bioRxiv · May 14, 2019 · PreprintGenomics