Direct long read visualization reveals metabolic interplay between two antimalarial drug targets
Shiwei Liu, Emily R. Ebel, Aleksander Łuniewski, Julia Zulawinska, Mary Lewis Simpson, Jane Kim, Nnenna Ene, Thomas Braukmann, Molly D. Congdon, Webster L. Santos, Ellen Yeh, Jennifer L. Güler
The paper uses long-read sequencing to show that increased copies of the GCH1 gene are associated with DHODH gene amplification in malaria parasites, suggesting a metabolic interplay between these two drug targets.
bioRxiv · Feb 13, 2023 · PreprintGenomics