Emily R. Ebel

The paper uses long-read sequencing to show that increased copies of the GCH1 gene are associated with DHODH gene amplification in malaria parasites, suggesting a metabolic interplay between these two drug targets.

The paper identifies extrachromosomal DNA enriched with var genes in Plasmodium falciparum, suggesting a mechanism for rapid antigenic diversification.

The paper investigates how common host red blood cell variation affects Plasmodium falciparum parasite growth in healthy humans, finding that non-pathogenic polymorphisms in RBC proteins significantly explain parasite fitness variation.