Jennifer L. Güler

Environmental stress promotes entry into a pre-existing latent state in Plasmodium falciparum

The paper shows environmental stress promotes latency in Plasmodium falciparum parasites, identified through single-cell transcriptomics, and identifies molecular features of this latent state.

SVCROWS: A User-Defined Tool for Interpreting Significant Structural Variants in Heterogeneous Datasets

SVCROWS improves structural variant interpretation by merging SVs with a size-weighted reciprocal overlap framework, maintaining accuracy and preserving rare genotypes in complex datasets.

Replication stress increases de novo CNVs across the malaria parasite genome

The paper shows replication stress increases de novo CNVs in Plasmodium falciparum, affecting genes involved in human infection.

HapCNV: A Comprehensive Framework for CNV Detection in Low-input DNA Sequencing Data

HapCNV improves CNV detection in low-input haploid sequencing data by using a pseudo-reference to reduce bias and enhance accuracy, especially for short CNVs.

Direct long read visualization reveals metabolic interplay between two antimalarial drug targets

The paper uses long-read sequencing to show that increased copies of the GCH1 gene are associated with DHODH gene amplification in malaria parasites, suggesting a metabolic interplay between these two drug targets.

Comparative analyses of parasites with a comprehensive database of genome-scale metabolic models

The paper presents a comparative analysis of 192 protozoan parasite genomes using a metabolic network reconstruction pipeline to identify species-specific metabolic differences and improve experimental system selection.

Single cell sequencing of the small and AT-skewed genome of malaria parasites

This paper develops a single cell sequencing pipeline for Plasmodium falciparum, improving genome amplification and copy number variation detection in single cells.

Novel Plasmodium falciparum metabolic network reconstruction identifies shifts associated with clinical antimalarial resistance