Author

Webster L. Santos

Virginia TechORCID 0000-0002-4731-8548Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:benchmarking· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:long-read sequencing· 1 Organism:mouse· 1

Frequent Co-Authors

Alban GaultieriD· 1 shared Aleksander Łuniewski· 1 shared Andrea R. MerchakiD· 1 shared Brant E. IsaksoniD· 1 shared Caitlin M. PaveleciD· 1 shared Daniel J. FosteriD· 1 shared Ellen YehiD· 1 shared Emily R. EbeliD· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperPharmacology & Toxicology

Alban GaultierORCID

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Author profile →

2 papers

Recent·Most cited

Assessing Spns2-dependent S1P Transport as a Prospective Therapeutic Target

Yugesh Kharel, Tao Huang, Kyle Dunnavant, Daniel J. Foster, George M. P. R. Souza, Katherine E. Nimchuk, Andrea R. Merchak, Caitlin M. Pavelec, Zuzanna J. Juśkiewicz, Simon S. Alexander, Alban Gaultier, Stephen B.G. Abbott, Jung‐Bum Shin, Brant E. Isakson, Wenhao Xu, , Kevin R. Lynch

This study evaluates a novel S1P transport blocker, SLF80821178, showing efficacy in multiple sclerosis without the cardiac side effects of SRMs, but with less lymphopenia and unchanged lymph S1P levels.

British Journal of Pharmacology · Feb 2, 2025Peer-reviewedPharmacology & Toxicology

Direct long read visualization reveals metabolic interplay between two antimalarial drug targets

Shiwei Liu, Emily R. Ebel, Aleksander Łuniewski, Julia Zulawinska, Mary Lewis Simpson, Jane Kim, Nnenna Ene, Thomas Braukmann, Molly D. Congdon, Webster L. Santos, Ellen Yeh, Jennifer L. Güler

The paper uses long-read sequencing to show that increased copies of the GCH1 gene are associated with DHODH gene amplification in malaria parasites, suggesting a metabolic interplay between these two drug targets.

bioRxiv · Feb 13, 2023 · PreprintGenomics