Membrane Expression Enhances Folding, Multimeric Structure Formation, and Immunogenicity of Viral Capsid Proteins
Junru Cui, Fangfeng Yuan, Jane Qin, Ju Hyeong Jeon, Dong Soo Yun, Tianlei Wang, Ren-Huan Xu, Hong Cao, Ashleigh A. Tungate, Christopher L. Netherton, Jianzhu Chen
This study enhances the immunogenicity of viral capsid proteins by engineering them into membrane-bound or secreted forms, showing improved folding and T cell responses in animal models.
ACS Infectious Diseases · Jul 9, 2025Peer-reviewedImmunology