Charles A. Whittaker

This study identifies tumor-intrinsic stress states as modulators of CAR T cell therapy response in pancreatic cancer using CRISPR screens and single-cell genomics.

The paper introduces INSIGHT, a platform for phosphoproteomic analysis of rare cell subpopulations, and applies it to study signaling changes in disseminated glioblastoma cells in vivo.

This study evaluates three cell preservation methods for scRNA-seq across multiple sites, showing concordant cell type results but platform-specific gene expression differences and better granulocyte retention with preservation methods.

This study compares pathogenesis of ancestral and contemporary Zika viruses in human cerebral organoids, finding differential signaling responses and identifying ROS imbalance as a key driver, which is mitigated by Trolox.

The paper selects and evaluates ASFV antigens for subunit mRNA vaccines, showing divergent immune responses and developing a computational method to design antigen cocktails.

This study shows that CDK9 degradation with KI-CDK9d-32 is more effective than inhibition in disrupting MYC transcriptional networks and causes MYC downregulation and nucleolar destabilization.

The paper uses CRISPR-Cas9 to knock out endogenous secreted proteins in Komagataella phaffii, increasing recombinant protein production by 20x.

The paper identifies molecular pathways underlying synaptic diversity between Drosophila tonic and phasic motoneurons through single-cell RNA profiling and genetic analysis.

This paper describes an engineered SARS-CoV-2 RBD variant that shows improved immunogenicity in mice and protective immunity in hamsters.