Internalization of myelin debris by neutrophils fuels inflammation
Mirre De Bondt, Janne Renders, Yana Sterckx, Sofie Vandendriessche, Jana Van Broeckhoven, Annet van de Waterweg Berends, Noëmie Pörtner, Lotte Vanbrabant, Vívian Louise Soares de Oliveira, Jeroen F. J. Bogie, Sam Vanherle, Pedro Elias Marques, Niels Hellings, Sofie Struyf
The paper shows human neutrophils internalize myelin debris via complement receptor 3, leading to a pro-inflammatory phenotype in MS.
bioRxiv · May 5, 2026 · PreprintImmunology