Author

Jared Z. Zhang

Brown University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 2

Signature Assays, Organisms & Methods

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Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Approach:statistical model· 1

Frequent Co-Authors

Courtney J. MercadanteiD· 2 shared Heather L. Kowalski· 2 shared Mariam Aghajan· 2 shared Milankumar PrajapatiiD· 2 shared Shuling GuoiD· 2 shared Thomas Benedict BartnikasiD· 2 shared Barry Chi Hong LaiiD· 1 shared Bradley Delaney· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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2 shared papersGenetics

Courtney J. MercadanteORCID

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2 papers

Recent·Most cited

Manganese transporter SLC30A10 and iron transporters SLC40A1 and SLC11A2 impact dietary manganese absorption

Milankumar Prajapati, Jared Z. Zhang, Grace S Chong, Lauren Chiu, Courtney J. Mercadante, Heather L. Kowalski, Olga A. Antipova, Barry Chi Hong Lai, Martina Ralle, Brian P. Jackson, Tracy Punshon, Shuling Guo, Mariam Aghajan, Thomas Benedict Bartnikas

The paper shows that SLC30A10 deficiency leads to increased manganese absorption via iron transporters SLC11A2 and SLC40A1, contributing to manganese excess and disease.

bioRxiv · Jul 17, 2024 · PreprintGenetics

Hypoxia-inducible factor 2 is a key determinant of manganese excess and polycythemia in SLC30A10 deficiency

Milankumar Prajapati, Jared Z. Zhang, Courtney J. Mercadante, Heather L. Kowalski, Bradley Delaney, Jessica A. Anderson, Shuling Guo, Mariam Aghajan, Thomas Benedict Bartnikas

This study identifies HIF2 as a key driver of erythropoietin excess and polycythemia in SLC30A10 deficiency by linking manganese toxicity to altered hepatic gene expression and hepcidin regulation.

bioRxiv · Feb 20, 2023 · PreprintGenetics