Author

Courtney J. Mercadante

Brown UniversityORCID 0000-0002-0678-9853Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Approach:statistical model· 1

Frequent Co-Authors

Heather L. Kowalski· 2 shared Jared Z. Zhang· 2 shared Mariam Aghajan· 2 shared Milankumar PrajapatiiD· 2 shared Shuling GuoiD· 2 shared Thomas Benedict BartnikasiD· 2 shared Barry Chi Hong LaiiD· 1 shared Bradley Delaney· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersGenetics

Heather L. Kowalski

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Manganese transporter SLC30A10 and iron transporters SLC40A1 and SLC11A2 impact dietary manganese absorption

Milankumar Prajapati, Jared Z. Zhang, Grace S Chong, Lauren Chiu, Courtney J. Mercadante, Heather L. Kowalski, Olga A. Antipova, Barry Chi Hong Lai, Martina Ralle, Brian P. Jackson, Tracy Punshon, Shuling Guo, Mariam Aghajan, Thomas Benedict Bartnikas

The paper shows that SLC30A10 deficiency leads to increased manganese absorption via iron transporters SLC11A2 and SLC40A1, contributing to manganese excess and disease.

bioRxiv · Jul 17, 2024 · PreprintGenetics

Hypoxia-inducible factor 2 is a key determinant of manganese excess and polycythemia in SLC30A10 deficiency

Milankumar Prajapati, Jared Z. Zhang, Courtney J. Mercadante, Heather L. Kowalski, Bradley Delaney, Jessica A. Anderson, Shuling Guo, Mariam Aghajan, Thomas Benedict Bartnikas

This study identifies HIF2 as a key driver of erythropoietin excess and polycythemia in SLC30A10 deficiency by linking manganese toxicity to altered hepatic gene expression and hepcidin regulation.

bioRxiv · Feb 20, 2023 · PreprintGenetics