Milankumar Prajapati

This paper identifies a novel mechanism by which manganese disrupts mitochondrial transcriptome processing, leading to dsRNA accumulation and neuroinflammation through MDA5 activation.

The paper shows that SLC30A10 deficiency leads to increased manganese absorption via iron transporters SLC11A2 and SLC40A1, contributing to manganese excess and disease.

This study identifies HIF2 as a key driver of erythropoietin excess and polycythemia in SLC30A10 deficiency by linking manganese toxicity to altered hepatic gene expression and hepcidin regulation.