Tau drives cell specific functional isolation of the hippocampal formation
Theodore J. Zwang, Jasen Zhang, Rudy Gelb-Bicknell, Nina Wolf, Viktor Chanchykov, Haoyang Zhu, Ergina Agastra, Ava Devine, Andrew J. Holbrook, Rachel E. Bennett, Bradley T. Hyman
This study shows that tau accumulation leads to neuronal silencing and network dysfunction in the hippocampal formation without neuron loss, contributing to progressive network disruption.
bioRxiv · Aug 10, 2025 · PreprintNeuroscience