Theodore J. Zwang

The paper uses subcellular spatial transcriptomics to identify why some neurons in Alzheimer's disease accumulate tau while others resist it, finding differences in molecular programs and neuron-glia interactions.

This study examines depth-dependent changes in cerebral oxygenation in Alzheimer's disease models, finding that tau disrupts oxygen levels and that neuronal loss is not due to local hypoxia.

The paper uses single-nucleus RNA-seq to analyze cerebrovascular transcriptomic changes in Alzheimer's Disease and primary tauopathies, identifying shared heat-shock responses and disease-specific vascular remodeling.

This study shows that transplanting GABAergic interneuron progenitors restores slow oscillation rhythms in Alzheimer's disease mouse models.

This study shows that tau accumulation leads to neuronal silencing and network dysfunction in the hippocampal formation without neuron loss, contributing to progressive network disruption.

JMod improves sequence identification and quantification in multiplexed DIA proteomics by jointly modeling overlapping mass spectra, enabling higher throughput with maintained accuracy.

The paper shows tau accumulates around blood vessels in Alzheimer's disease brains and is linked to tau tangle pathology.

The paper investigates synaptic instability in experimental autoimmune encephalomyelitis, finding that excitatory synapses become unstable and reorganize before symptom onset, altering circuit inputs to cortical neurons.