Author

Andrew J. Holbrook

University of California, IrvineORCID 0000-0002-3558-200XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Research Focus:dimensionality reduction· 1 Assay:electronic health records· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:imaging· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

Alzheimer’s Disease Neuroimaging Initiative· 1 shared Ava Devine· 1 shared Bradley T. HymaniD· 1 shared Brian AvantsiD· 1 shared Daniel L. GilleniD· 1 shared Ergina Agastra· 1 shared Haoyang Zhu· 1 shared James R. Stone· 1 shared

Activity by Year

2018-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperNeuroscience

Alzheimer’s Disease Neuroimaging Initiative

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2 papers

Recent·Most cited

Tau drives cell specific functional isolation of the hippocampal formation

Theodore J. Zwang, Jasen Zhang, Rudy Gelb-Bicknell, Nina Wolf, Viktor Chanchykov, Haoyang Zhu, Ergina Agastra, Ava Devine, Andrew J. Holbrook, Rachel E. Bennett, Bradley T. Hyman

This study shows that tau accumulation leads to neuronal silencing and network dysfunction in the hippocampal formation without neuron loss, contributing to progressive network disruption.

bioRxiv · Aug 10, 2025 · PreprintNeuroscience

The ANTs Longitudinal Cortical Thickness Pipeline

Nicholas James Tustison, Andrew J. Holbrook, Brian Avants, Jared M. Roberts, Philip A. Cook, Zachariah M. Reagh, Jeffrey Duda, James R. Stone, Daniel L. Gillen, Michael A. Yassa, Alzheimer’s Disease Neuroimaging Initiative

The paper introduces an ANTs-based longitudinal cortical thickness pipeline and demonstrates its effectiveness in analyzing ADNI-1 data for detecting structural brain changes over time.

bioRxiv · Aug 16, 2018 · PreprintNeuroscience