Author

Ergina Agastra

Massachusetts General Hospital

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 1 Assay:electronic health records· 1 Approach:experimental assay· 1 Organism:human· 1 Organism:mouse· 1 Assay:snRNA-seq· 1 Approach:statistical model· 1

Frequent Co-Authors

Bradley T. HymaniD· 2 shared Rachel E. BennettiD· 2 shared Theodore J. ZwangiD· 2 shared Aicha Abdourahman· 1 shared Akhila Gundavelli· 1 shared Alberto Serrano‐PozoiD· 1 shared Andrew J. HolbrookiD· 1 shared Annita Martin· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersNeuroscience

Bradley T. HymanORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Cerebrovascular Single-Nucleus RNA-Seq Reveals Heat Shock Activation and Vascular Remodeling in Alzheimer's Disease and Primary Tauopathies

L. Daniel Estrella, Swarnali Dasgupta, Akhila Gundavelli, Huan Li, Stanley Yang, Sarah E. Chancellor, Tim Pastika, Aicha Abdourahman, Joseph A. Tamm, Kiran Yanamandra, Nandani Romanul, Fan Liao, Karen Zhao, Gen Lin, Pooja Srinivasa, , Rachel E. Bennett

The paper uses single-nucleus RNA-seq to analyze cerebrovascular transcriptomic changes in Alzheimer's Disease and primary tauopathies, identifying shared heat-shock responses and disease-specific vascular remodeling.

bioRxiv · Jun 28, 2026 · PreprintNeuroscience

Tau drives cell specific functional isolation of the hippocampal formation

Theodore J. Zwang, Jasen Zhang, Rudy Gelb-Bicknell, Nina Wolf, Viktor Chanchykov, Haoyang Zhu, Ergina Agastra, Ava Devine, Andrew J. Holbrook, Rachel E. Bennett, Bradley T. Hyman

This study shows that tau accumulation leads to neuronal silencing and network dysfunction in the hippocampal formation without neuron loss, contributing to progressive network disruption.

bioRxiv · Aug 10, 2025 · PreprintNeuroscience