Neutrophil extracellular traps block endogenous and intravenous thrombolysis-induced fibrinolysis in large vessel occlusion acute ischemic stroke
Jean‐Philippe Désilles, Mialitiana Solo Nomenjanahary, Astride Perrot, Lucas Di Meglio, Fatima Zemali, Sara Zalghout, Stéphane Loyau, Julien Labreuche, Marie‐Charlotte Bourrienne, Dorothée Faille, François Delvoye, Véronique Ollivier, Sébastien Dupont, Jasmina Rogozarski, Nahida Mokhtari Brikci-Nigassa, , Benoît Ho‐Tin‐Noé
This study shows that neutrophil extracellular traps (NETs) inhibit fibrinolysis during intravenous thrombolysis in acute ischemic stroke by sequestering tPA and plasminogen, and that DNase 1 can enhance thrombolysis by removing NETs.
bioRxiv · Mar 28, 2025 · PreprintPathology