Benoît Ho‐Tin‐Noé

This study develops a dual-action nanoconjugate combining r-tPA and DNase to target r-tPA-resistant clots, showing improved reperfusion and reduced lesion volume in an ischemic stroke model.

This study identifies venular-centered thrombo-inflammation as a key driver of microvascular failure after arterial recanalization in acute mesenteric ischemia, using both human and murine models.

This study shows that neutrophil extracellular traps (NETs) inhibit fibrinolysis during intravenous thrombolysis in acute ischemic stroke by sequestering tPA and plasminogen, and that DNase 1 can enhance thrombolysis by removing NETs.