Author

Jean‐Philippe Désilles

InsermORCID 0000-0001-8395-6312Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Astride Perrot· 1 shared Benoît Ho‐Tin‐NoéiD· 1 shared Dorothée FailleiD· 1 shared Fatima Zemali· 1 shared François DelvoyeiD· 1 shared Jasmina Rogozarski· 1 shared Julien LabreucheiD· 1 shared Lucas Di MeglioiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperPathology

Astride Perrot

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1 paper

Recent·Most cited

Neutrophil extracellular traps block endogenous and intravenous thrombolysis-induced fibrinolysis in large vessel occlusion acute ischemic stroke

Jean‐Philippe Désilles, Mialitiana Solo Nomenjanahary, Astride Perrot, Lucas Di Meglio, Fatima Zemali, Sara Zalghout, Stéphane Loyau, Julien Labreuche, Marie‐Charlotte Bourrienne, Dorothée Faille, François Delvoye, Véronique Ollivier, Sébastien Dupont, Jasmina Rogozarski, Nahida Mokhtari Brikci-Nigassa, , Benoît Ho‐Tin‐Noé

This study shows that neutrophil extracellular traps (NETs) inhibit fibrinolysis during intravenous thrombolysis in acute ischemic stroke by sequestering tPA and plasminogen, and that DNase 1 can enhance thrombolysis by removing NETs.

bioRxiv · Mar 28, 2025 · PreprintPathology