Low dose AKT inhibitor miransertib cures PI3K-related vascular malformations in preclinical models of human disease
Piotr Kobialka, Helena Sabata, Odena Vilalta, Ana Angulo‐Urarte, Laia Muixí, Jasmina Zanoncello, Oscar Muñoz‐Aznar, Nagore Gené Olaciregui, Cinzia Emilia Lavarino, Verónica Celis, Carlota Rovira, Susana López Fernández, Eulàlia Baselga, Jaume Mora, Sandra D. Castillo, Mariona Graupera
The paper develops a preclinical model of PI3K-driven vascular malformations and shows that low-dose AKT inhibitor miransertib prevents and regresses these malformations in mice and human endothelial cells.
bioRxiv · Jul 16, 2021 · PreprintMolecular Biology