Author

Sandra D. Castillo

Josep Carreras Leukaemia Research InstituteORCID 0000-0002-7007-3155Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Developmental Biology· 1 Genomics· 1 Molecular Biology· 1 Pathology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 4 Organism:mouse· 3 Organism:human· 2 Assay:ChIP-seq· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Assay:Hi-C· 1

Frequent Co-Authors

Mariona GrauperaiD· 4 shared Ana Angulo‐UrarteiD· 2 shared Eulàlia BaselgaiD· 2 shared Helena SabataiD· 2 shared Susana López Fernández· 2 shared Agnès Figueras· 1 shared Alberto Collado-Remacha· 1 shared Aleksey LazarenkoviD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersPathology

Mariona GrauperaORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

ERK overstimulation leads to cell hyperproliferation in hereditary hemorrhagic telangiectasia landscape

JOSE LUIS ROCAMORA, Anna Casellas, Agnès Figueras, Pau Cerdà, Ferran Medina‐Jover, Raquel Torres-Iglesias, Sandra D. Castillo, Mariona Graupera, Roxana Ola, Antoni Riera‐Mestre, Francesc Viñals

This study shows that ERK overactivation contributes to endothelial cell hyperproliferation in HHT, suggesting ERK inhibition as a potential therapy.

bioRxiv · Jul 11, 2026 · PreprintPathology

Context-dependent response of endothelial cells to PIK3CA mutation

Helena Sabata, Ariadna Roca-Coll, Jose A. Dengra, Leonor Gouveia, Ane Martinez‐Larrinaga, Alberto Collado-Remacha, Sandra D. Castillo, Elena Castillo, Nathalie Tisch, Macarena De Andrés-Laguillo, Svanhild Nornes, Judith Llena, Pilar Villacampa, Bart Vanhaesebroeck, Maria Pilar Alcolea, , Mariona Graupera

This study shows that PIK3CAH1047R mutation causes clonal expansion in capillary and venous endothelial cells but not in arterial cells, revealing stage-dependent responses and a protective mechanism against arterial damage.

bioRxiv · Feb 25, 2025 · PreprintDevelopmental Biology

p53 rapidly restructures 3D chromatin organization to trigger a transcriptional response

François Serra, Andrea Nieto-Aliseda, Lucía Fanlo, Llorenç Rovirosa, Mónica Cabrera-Pasadas, Aleksey Lazarenkov, Blanca Urmeneta, Alvaro Alcalde-Merino, E. Nola, Andrei L. Okorokov, Peter Fraser, Mariona Graupera, Sandra D. Castillo, José Luis Sardina, Alfonso Valencia, Biola M. Javierre

This study shows p53 rapidly changes 3D chromatin structure to regulate gene transcription, identifying 340 new direct target genes.

Nature Communications · Apr 1, 2024Peer-reviewedGenomics

Low dose AKT inhibitor miransertib cures PI3K-related vascular malformations in preclinical models of human disease

Piotr Kobialka, Helena Sabata, Odena Vilalta, Ana Angulo‐Urarte, Laia Muixí, Jasmina Zanoncello, Oscar Muñoz‐Aznar, Nagore Gené Olaciregui, Cinzia Emilia Lavarino, Verónica Celis, Carlota Rovira, Susana López Fernández, Eulàlia Baselga, Jaume Mora, Sandra D. Castillo, Mariona Graupera

The paper develops a preclinical model of PI3K-driven vascular malformations and shows that low-dose AKT inhibitor miransertib prevents and regresses these malformations in mice and human endothelial cells.

bioRxiv · Jul 16, 2021 · PreprintMolecular Biology