Cinzia Emilia Lavarino

Variable latency between the founder genetic event and rhabdoid tumor expansion

The paper estimates the timing of genetic driver events and clonal expansion in rhabdoid tumors using whole-genome sequencing data from 97 tumors.

USP7 sustains PAX3::FOXO1 enhancer reprogramming and represents a therapeutic vulnerability in Rhabdomyosarcoma

This study identifies USP7 as a critical regulator of PAX3::FOXO1 enhancers in FP-RMS and shows its inhibition reduces tumor growth.

Spatio-temporal T cell tracking for personalized TCR-T designs in childhood cancer

This study tracks T cell dynamics in a pediatric cancer patient post-ICI therapy to identify tumor-reactive TCRs for personalized TCR-T cell therapy.

Neural crest-related NXPH1/α-NRXN signaling opposes neuroblastoma malignancy by inhibiting metastasis

The paper identifies a transcriptional signature distinguishing low- and high-risk neuroblastomas and shows that NXPH1/-NRXN signaling inhibits metastasis while promoting tumor growth.

Low dose AKT inhibitor miransertib cures PI3K-related vascular malformations in preclinical models of human disease

The paper develops a preclinical model of PI3K-driven vascular malformations and shows that low-dose AKT inhibitor miransertib prevents and regresses these malformations in mice and human endothelial cells.