Tumor cell dissemination is facilitated through regulatory T cell-driven extracellular matrix remodeling
Ailen D. Garcia-Santillan, Jessanne Y. Lichtenberg, He Shen, Jasmine M. Rodriguez, Sandra Makar, Jonathan Barra, Nicholas M. Clark, Wei Du, Leandro Marcelo Martinez, Ashley D. Hadjis, Taylor Calicchia, Mikhail G. Dozmorov, Jose Javier Bravo‐Cordero, Amy L. Olex, Priscilla Y. Hwang, Paula D. Bos
This study shows Treg cells remodel the tumor ECM to promote metastasis, with matrisome signatures linked to poor survival in breast cancer.
bioRxiv · Oct 25, 2025 · PreprintCancer Biology